Nuclear Antigens

• Ki-67 - proliferation related antigen

• Ki-S1 - proliferation related antigen

• Cyclin A: expression begins in late G1/early S phase and increases as cells traverse S phase, reaching a maximum in G2. Cyclin A is not expressed in mitotic cells

• Cyclin B1: accumulates in late S phase but is maximally expressed in G2 and mitosis.

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