School of Veterinary Medicine, Department of Basic Medical Sciences, Purdue University
Graduate Student Profile
Karen K. Cornell D.V.M
Dr. Karen Cornell
Hansen Hall, B050
Purdue University
West Lafayette, IN 47907
Ph: (317) 494 0757
Fax: (317) 494 0517
For a good time email me at karen@flowcyt.cyto.purdue.edu
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Position:
Clinical Investigator - Basic Medical Sciences
Previous Training:
Doctor of Veterinary Medicine 1988 - Purdue School of Veterinary Medicine
Veterinary Associate - Private Practice, Evansville, IN 1988-1990
Small Animal Internship - Purdue School of Veterinary Medicine 1990-1991
Small Animal Surgical Residency - Purdue School of Veterinary Medicine 1991-1994
Research Areas
Elucidation of the Complex Mechanisms of Metastasis
A. Tumor cell-extracelluar matrix interactions
We are studying the activities of proteases which play a vital role in cancer metastasis by degrading
extracellular matrix. We are evaluating these proteases, including metalloproteinases, serine proteases, and cysteine proteases, within tumor cells and stromal cells in the tumor environment.
B. Tumor cell-stromal cell interactions such as growth factor production/signaling
Tumor cell invasion and motility may be greatly influenced by cytokines produced by stromal
cells in the environment; we are specifically looking at tumor-cell fibroblast interactions in
human prostate cancer.
C. Tumor cell-tumor cell interactions
Homotypic adhesion may play an important role in metastasis. We are attempting
to modulate E-cadherin expression in tumor cells in culture.
D. Tumor cell - endothelial cell interactions at the metastatic target organ.
Adhesion to and penetration of metastatic tumor cells through the endothelial cells of the
target organ are critical to metastatic competence. We plan to evaluate those interactions
in human prostate cancer.
E. In vivo studies using athymic nude mice for establishing metastatic models.
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For information about the Purdue University Cytometry Laboratories contact:
J.Paul Robinson, Director, PUCL, Hansen Hall, B050, Purdue University, West Lafayette, IN. 47907. Ph: (317) 494 0757; Fax (317) 494 0517. Send an email message to Dr.Robinson at robinson@flowcyt.cyto.purdue.edu