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determine if there are activation defects in HIV patients. Our data indi=
cated =
that in early stage (asymptomatic) HIV patients 30% have a reduced respon=
se to =
Cd2/2r while 70% of the late stage patients show this same type of respon=
se. =
This "response" does not seem to be correlated with viral load but when u=
sing =
multivarient analysis we showed that changes in CD4+CD26+ and CD4+FAS cel=
l =
populations can be predictive of changes in the Cd69 response to CD2/2r. =
=
Currently our group is involved in a longitudinal study to validate these=
=
findings and to study the effects of treatment on Immune kinetics.
Stephen P. Perfetto
Department of HIV Disease Prevention
Walter Reed Army Institute of Research
1600 East Gide Drive
Rockville, MD. 20850
_________________________________________________________________________=
______
Subject: LTT with CD 69-Assay??
From: owner-cyto-sendout@flowcyt.cyto.purdue.edu at Internet_Gateway
Date: 11/30/95 10:50 AM
Hi, all there out!
I've just heard about some new BD-Kit named "FAST IMMUNE Assay system". I=
t
should replace the former LTT-Test. Principle is to detect the CD 69 as e=
arly
indicator for Lymphocyte activation. So far so well!
Has anybody just worked with this or a similar test-Kit?
Is CD 69 a real representativ for 'Lymphocyte Transformation'?
Thanks in advance
M.
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