School of Veterinary Medicine, Department of Basic Medical Sciences, Purdue University
Faculty Profile
J. Paul Robinson, Ph.D.
Positions:
Professor of Immunopharmacology
Director, Purdue University Cytometry Laboratories
Research Areas:
Tissue Injury
Our research has involved developing a better understanding of the role
of oxidants in tissue injury. We have developed several new technologies
for measuring intracellular oxidants in viable cells. The purpose of these
studies is to understand better the causes of infection, and tissue damage
secondary to trauma related injuries. If we can intervene to modify the
subsequent tissue damage caused by the immune system, this may allow us
to develop better therapies for seriously injured patients. Our studies
involve tissue culture of endothelial cells and a model has been established
to replicate neutrophil-induced tissue damage.
Immune effects of toxic chemicals
The second area of concern in our lab involves the effect of polychlorinated
biphenols (pcbs) on the immune response of individuals. We have developed
cell culture systems for evaluation of the effect pcbs have on differentiation
and cell function of HL-60 cells. We have also performed many studies on
human neutrophils and have shown effects of pcb on the ability of neutrophils
to function normally. A significant recent finding has been that some pcbs
are capable of binding and inactivating superoxide dismutase, an important
enzyme in all cells in the body for removing superoxide anions, potentially
dangerous reactive oxygen species. It is therefore possible that continuous
low concentrations of pcbs are capable of increasing the sensitivity of
tissue to dangerous reactive oxygen species.
Graduate Program:
Several slots are available for Ph.D students in this laboratory. For information
regarding graduate studies write to the Head of the Graduate Program
or email directly to the Administrative Assistant
(Graduate Programs) to receive a graduate package Send an email request
now for a graduate package:
sue@vet.purdue.edu or....
send an email directly to Dr. Robinson for further information.
Send an email message now to Dr. Robinson:
robinson@flowcyt.purdue.edu
Laboratory Facilities:
Instrumentation is detailed in the following section. Laboratory
space includes cell culture facilites, animal
housing, flow cytometry and confocal microscopy instrumentation areas,
preparation areas and engineering development space.
The laboratory is situated in the Cancer Center (Hansen Hall) and also houses
the Analytical Cytology Core of the Cancer Center.
Educational Activities
Activities within the Laboratory:
Connect to the Australian & New
Zealand Scientists Connection
An FTP site is available to send and receive files, images, or other
information to the department
[FTP to PURDUE now].
To return to PUCL Homepage ....Press here
For information about the Department of Basic Medical Sciences contact:
Gordon L. Coppoc, D.V.M., Ph.D., Head,
Department of Basic Medical Sciences, Lynn Hall,
Purdue University, West Lafayette, IN 47907-1246, U.S.A. Phone: (317) 494-8632 Fax: (317) 494-0781. Send an email message to Dr.Coppoc at coppoc@vet.purdue.edu
CD ROM Vol 2 was produced by staff at the Purdue University Cytometry Laboratories
and distributed free of charge as an educational service to the cytometry community.
If you have any comments please direct them to Dr. J. Paul Robinson, Professor & Director, PUCL,
Purdue University, West Lafayette, IN 47907. Phone:(317) 494-0757; FAX (317) 494-0517; Web http://www.cyto.purdue.edu
EMAIL robinson@flowcyt.cyto.purdue.edu
