- Think about safety margins
Example: penicillin G versus gentamicin
- Think of ease of "bioassaying" the drug in the patient, i.e., presence of
easily detectable and rapid response
Example: anticonvulsant versus anesthetic agent
- What if signs of too little and too much drug are similar?
Example: digoxin
- When interindividual variation is much greater in
DOSE vs PLASMA CONCENTRATION than in
PLASMA CONCENTRATION vs EFFECT!
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Last modified: 8/18/96 glc