vProblem Frameset

<body> <p><script language="JavaScript"> </script> </p> <h1 align="center"><a name="top" target="mainFrame">Problems related to Vd & LD</a></h1> <p align="left"><strong>  </strong><a name="Problem 01." target="mainFrame"><strong>Problem 01.</strong></a> A drug has a volume of distribution of 300 L in a 500 Kg horse.</p> <ol> <li>What is its Vd in L/Kg? <br> <form><script="JavaScript"><INPUT TYPE="BUTTON" VALUE="answer" ONCLICK="report(this.form,'01')"> <INPUT TYPE="BUTTON" VALUE="Clear" ONCLICK="clearfr('answer_frame')"></script> </form> </li> </ol> <p align="left"><a name="Problem 02" target="mainFrame"><strong>Problem 02</strong></a><strong>.</strong> A drug has a volume of distribution of 0.3 L/Kg. [<a href="vstdnt01.htm#Vd & LD questions" target="mainFrame">Student Question</a>]</p> <ol> <li>What is the total Vd in a 15 Kg Beagle?</li> <li>What is the total Vd in a 40 pound Beagle?<br> <form><script="JavaScript"><INPUT TYPE="BUTTON" VALUE="answer" ONCLICK="report(this.form,'02')"> <INPUT TYPE="BUTTON" VALUE="Clear" ONCLICK="clearfr('answer_frame')"></script> </form> </li> </ol> <p align="left"><a name="Problem 03" target="mainFrame"><strong>Problem 03</strong></a><strong>.</strong> A drug was given IV to a 70 Kg calf at a dose of 2.5 mg/Kg. Concentrations of drug in plasma were found to be the as follows (mg/L): 2 hr = 7.07; 4 hr = 5.00; 6 hr = 3.54; 8 hr = 2.50.</p> <ol> <li>What is the total dose?</li> <li>What is the Cp(0)?</li> <li>What is the Vd/Kg?</li> <li>What is the whole animal Vd?<br> <form><script="JavaScript"><INPUT TYPE="BUTTON" VALUE="answer" ONCLICK="report(this.form,'03')"> <INPUT TYPE="BUTTON" VALUE="Clear" ONCLICK="clearfr('answer_frame')"></script> </form> </li> </ol> <p><a name=" Problem 04" target="mainFrame"><strong> Problem 04</strong></a><strong>.</strong> A drug was given IV to a 3 Kg cat at a dose of 5 mg/Kg. The resulting Cp(0) was 20 mg/L. The same dose of drug was given to the cat 1 month later by mouth and the animal had no significant change in weight or hydration status. The resulting Cp(0) was 17 mg/L. Assume both of these values were "correct." [<a href="vstdnt01.htm#Vd & LD questions" target="mainFrame">Student Question</a>]</p> <ol> <li>What is the approximate F? </li> <li>What formula did you use to calculate F? </li> <li>How does it compare to the approach described in class? <br> <form><script="JavaScript"><INPUT TYPE="BUTTON" VALUE="answer" ONCLICK="report(this.form,'04')"> <INPUT TYPE="BUTTON" VALUE="Clear" ONCLICK="clearfr('answer_frame')"></script> </form> </li> </ol> <p><a name="Problem 05" target="mainFrame"><strong>Problem 05</strong></a><strong>.</strong> A drug was given IV to an animal that had an estimated Vd of 0.9 L/Kg. The dose was 4 mg/Kg.</p> <ol> <li>What is the estimated Cp(0)?</li> <li>What is the estimate of F?</li> <li>How does this Cp(0) correspond to the "A" in the one-compartment pharmacokinetic model?<br> <form><script="JavaScript"><INPUT TYPE="BUTTON" VALUE="answer" ONCLICK="report(this.form,'05')"> <INPUT TYPE="BUTTON" VALUE="Clear" ONCLICK="clearfr('answer_frame')"></script> </form> </li> </ol> <p><a name="Problem 06" target="mainFrame"><strong>Problem 06</strong></a>. A drug was given PO to an animal that had an estimated Vd of 0.6 L/Kg. The dose was 3 mg/Kg and the literature states the F for this drug give PO is 0.8.</p> <ul> <li>What is the highest possible value for Cp(0) in this case?</li> <li>Is the actual value going to be higher or lower that this?<br> (Remember Cp(0) in this case would be the extrapolated value.)<br> <form><script="JavaScript"><INPUT TYPE="BUTTON" VALUE="answer" ONCLICK="report(this.form,'06')"> <INPUT TYPE="BUTTON" VALUE="Clear" ONCLICK="clearfr('answer_frame')"></script> </form> <br> </li> </ul> <p><a name="Problem 07" target="mainFrame"><strong>Problem 07</strong></a>. You are treating a 25 pound terrier with a drug that has a Vd of 0.4 L/Kg and you want the concentration to be in the range of 15 mg/L.</p> <ul> <li>How much drug should you give IV for the initial dose (LD)?<br> <form><script="JavaScript"><INPUT TYPE="BUTTON" VALUE="answer" ONCLICK="report(this.form,'07')"> <INPUT TYPE="BUTTON" VALUE="Clear" ONCLICK="clearfr('answer_frame')"></script> </form> </li> </ul> <p><a name="Problem 08" target="mainFrame"><strong>Problem 08</strong></a><strong>.</strong> You are treating a 15 Kg dog with a drug that has a Vd of 0.3 L/Kg, a PO F=0.6, and you want a Cp(0) of 10 mg/L.</p> <ul> <li>How much drug should you give PO to this dog?<br> <form><script="JavaScript"><INPUT TYPE="BUTTON" VALUE="answer" ONCLICK="report(this.form,'08')"> <INPUT TYPE="BUTTON" VALUE="Clear" ONCLICK="clearfr('answer_frame')"></script> </form> </li> </ul> <p><form><script="JavaScript"><INPUT TYPE="BUTTON" VALUE="show all answers" ONCLICK="show_all()"> <INPUT TYPE="BUTTON" VALUE="Clear" ONCLICK="clearfr('answer_frame')"></script> </form></p> <hr size="4"> <hr size="4"> <table border="1" width="50%"> <tr> <td align="center" width="33%"><a href="index.htm" target="mainFrame"><font size="2">index</font></a></td> <td align="center" width="33%"><a href="lo_main.htm#main_menu" target="mainFrame"><font size="2">vet lecture menu</font></a></td> <td align="center" width="34%"><a href="vhmwrk01.htm" target="mainFrame"><font size="2">Problem menu</font></a></td> </tr> </table> <address> <a href="mailto:coppoc@vet.purdue.edu" target="mainFrame">Send suggestions / questions </a><br> Last modified: 05 Sep 1996 18:39 <a href="gordonl.htm" target="mainFrame">glc</a> </address> </body>