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Maryalice
>Hi everyone,
>We recently processed a hepatosplenic lymphoma in an 18 y/o BM which was ve=
ry
>aggressive and which had the following phenotype:
>CD2+, CD3+, CD5-, CD7+, gamma/delta-TCR+, alpha/beta-TcR+, CD4-, CD8=D2, CD=
56+,
>and CD11c+. It showed J-Beta rearrangement bands, and this resembles the ra=
re,
>but previously reported cases of aggressive gamma-delta T cell lymphomas.
>Checking several times, we confirmed the coexistence of the two forms of T
>cell
>receptor (a/b, g/d) on the cell surface. I have never seen any T cell
>tumor that
>coexpressed two TCR forms and I would appreciate any comments or advice fro=
m
>those of you who may have had previous experience with a similar tumor.
>
>Thanks,
>
>Phil Ruiz
>U. of Miami
Maryalice Stetler-Stevenson
Director Flow Cytometry Unit
Laboratory of Pathology, NCI, NIH
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CD-ROM Vol 3 was produced by Monica M. Shively and other staff at the
Purdue University Cytometry Laboratories and distributed free of charge
as an educational service to the cytometry community.
If you have any comments please direct them to
Dr. J. Paul Robinson, Professor & Director,
PUCL, Purdue University, West Lafayette, IN 47907.
Phone: (765)-494-0757;
FAX(765) 494-0517;
Web