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Maryalice
>MaryAlice,
>
> Should you run FMC7 if you have cd19+, cd23-/cd5+ lymphoma? Our
>pathologist, when I approached him with this, believes it isn't
>necessary. You already, if the histology agrees, have a mantle zone
>presentation without FMC7 positivity.
>
> For our lymphoma panels we run cd3/cd19, cd5, cd10, cd23, kappa, lambda
>for B, appropriate T markers if not B.
>
>thanks,
>
>hugh johnson
>flow lab guy
>st vincent infirmary medical center
>little rock, ar
>>Maryalice Stetler-Stevenson wrote:
>>
>> I can't cite statistics but from our clinical experience, FMC7 is extremely
>> sensitive for mantle cell but not specific (many other lymphomas are FMC7
>> positive). I have never had a real mantle cell lymphoma that was FMC7
>> negative (most consistent with Mantle cell doesn't count as these are
>> usually something in between real mantle cell and something else). It is
>> useful in differentiating CD5+ neoplasms with the appropriate morphology. A
>> CD5+ neplasm that is FMC7+ and CD23- and has small lymphoid cells with
>> compact chromatin as well as some what cleaved nuclei is mantle cell. But
>> then of course, nothing stands alone in diagnosis of neoplasia. If you have
>> a specific example, what are the other antigens studied?
>>
>> Maryalice
>>
>> >HEY,
>> >DOES ANYONE KNOW THE SENSITIVITY AND SPECIFICITY OF FMC7 IN THE FACE OF A
>> >PICTURE THAT APPEARS TO REPRESENT INTERMEDIATE CELL (MANTLE CELL OR ZONE)
>> >LYMPHOMA IN HUMANS (FOR YOU PURISTS). THANKS SO MUCH, MELISSA L. BEAL, M.D.
Maryalice Stetler-Stevenson
Director Flow Cytometry Unit
Laboratory of Pathology, NCI, NIH
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CD-ROM Vol 3 was produced by Monica M. Shively and other staff at the
Purdue University Cytometry Laboratories and distributed free of charge
as an educational service to the cytometry community.
If you have any comments please direct them to
Dr. J. Paul Robinson, Professor & Director,
PUCL, Purdue University, West Lafayette, IN 47907.
Phone: (765)-494-0757;
FAX(765) 494-0517;
Web