B cell lymphocytosis

Gerald E. Marti (gemarti@helix.nih.gov)
Sat, 2 Dec 1995 12:42:13 -0500

In June 1995 a USPHS Workshop on Laboratory and Epidemiologic Approaches to
Determining the Role of Environmental Exposures as Risk Factors for Chronic
Lymphocytic Leukemia and Other B-Cell Lymphoproliferative Disorders was
held in Atlanta.

A major question raised at this workshop was:what is the incidence of
monoclonal B cell lymphocytosis (with and without CD5 expression)? It is
my impression that most clincal flow cytometry labs encounter or find B-CLL
like clones in asymptomatic individuals with only a slightly elevated or
normal absloute lymphocye count from time to time. How frequent is this?
Age and sex?

I would be interested in knowing how widespread this phemnomena is. Are
there a sufficient number of such individuals to warrent a report? Could a
cohort be followed over time? How are these individuals being followed
presently? Will compile responses later. Thank you. gemarti

Gerald E. Marti
Flow and Image Cytometry Section
Laboratory of Medical and Molecular Genetics
Division of Cell and Gene Therapies
CBER FDA NIH Bdg 29B Rm 2NN08
8800 Raockville Pike
Bethesda,MD 20892

301-827-0453 (voice)
301-827-0449 (fax)

Home Page Table of Contents Sponsors Web Sites
CD ROM Vol 2 was produced by staff at the Purdue University Cytometry Laboratories and distributed free of charge as an educational service to the cytometry community. If you have any comments please direct them to Dr. J. Paul Robinson, Professor & Director, PUCL, Purdue University, West Lafayette, IN 47907. Phone:(317) 494-0757; FAX (317) 494-0517; Web http://www.cyto.purdue.edu EMAIL robinson@flowcyt.cyto.purdue.edu