Re: AML
Anna Porwit-MacDonald (anpo@mb.ks.se)
Tue, 21 Jan 1997 13:24:32 +0100
>
> We have just seen a case that is suspected of being AML but is
> positive for CD13 only. It is negative for all other markers
> including CD45. This patient has presented with bilateral renal
> masses and a deep iliac mass. A random bone marrow showed a diffuse
> infiltrate of blast cells believed to be myeloid but only CD13
> positive. Has anyone else seen any AMLs that are only positive for
> CD13?
>
> Thanks for the help.
>
> Haywood Pyle
> pyle@kfshrc.edu.sa
>
>Hi!
I have not seen such a case in a rather large material
(approx.300 cases studied) !
Did you check cytoplasmic staining for CD22, CD3, myeloperoxidase? Is CD117
and CD56 also negative?
CD13 reacts with aminopeptidase-N (ref. among others Favaloro et al,
Leukocyte typing V,p.1788, Oxford University Press 1995), so it is not
impossible that non-hematopoietic tumors may react. Is it possible to
perform cytochemistry (eg chloracetate esterase) on cytologic material?
Would be grateful to know the facit when you have it!
Best wishes
Anna Porwit-MacDonadl
Haematopathology Lab., Department of Pathology,
Karolinska Hopital, Stockholm
>