>
> >
> > We have just seen a case that is suspected of being AML but is
> > positive for CD13 only. It is negative for all other markers
> > including CD45. This patient has presented with bilateral renal
> > masses and a deep iliac mass. A random bone marrow showed a diffuse
> > infiltrate of blast cells believed to be myeloid but only CD13
> > positive. Has anyone else seen any AMLs that are only positive for
> > CD13?
> >
> > Thanks for the help.
> >
> > Haywood Pyle
> > pyle@kfshrc.edu.sa
> >
> >Hi!
> I have not seen such a case in a rather large material
> (approx.300 cases studied) !
> Did you check cytoplasmic staining for CD22, CD3, myeloperoxidase? Is CD117
> and CD56 also negative?
> CD13 reacts with aminopeptidase-N (ref. among others Favaloro et al,
> Leukocyte typing V,p.1788, Oxford University Press 1995), so it is not
> impossible that non-hematopoietic tumors may react. Is it possible to
> perform cytochemistry (eg chloracetate esterase) on cytologic material?
> Would be grateful to know the facit when you have it!
> Best wishes
> Anna Porwit-MacDonadl
> Haematopathology Lab., Department of Pathology,
> Karolinska Hopital, Stockholm
> >
>
> I agree with Anna and her questions. I have not seen a case like this
in about 1,000 cases of AML studied.
Regards, Elisabeth Paietta