Two Compartment Model

Definition and assumptions
2-COM formula

Definition: The two compartment open model treats the body as two compartments. Input and output are from the central compartment. Mixing occurs between the two compartments.
- [full] Figure: Box diagram
- [full] Figure: Plot of 2-COM with terms
Assumptions
- Mixing is instantaneous in within each compartment
- Input and output are from the "central" compartment
- Mixing between the compartments is slow relative to mixing within the compartments

2-COM formula (alpha, beta, A, B)

[full] Figure: Plot of 2-COM with terms
[do_plot] Plot 2-COM formula and enter various values for parameters. (NOTE: You must have Microsoft Excel installed on your machine and your browser must be appropriately setup for this to work)

Cp(t) = A * e^{-(alpha
* t)}+ B * e^{-(beta * t)}

Cp(t) = plamsa drug concentration at time "t"
A = Intercept of first term (process)
B = Intercept of second term (process)
alpha = -slope of first term
beta = -slope of second term
[By convention, the slowest process is placed as the second term]

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Last modified: 8/25/96 03 Sep 1996 22:34 glc

Two Compartment Model

Definition and assumptions

2-COM formula (alpha, beta, A, B)